This protocol addresses patients with uncomplicated acute mastoiditis — a non-invasive presentation with fluid in the mastoid air cells and no history of severe allergy (anaphylaxis) to penicillins — whose condition has not responded to the initial antibiotic regimen within the expected window.
Uncomplicated acute mastoiditis · Non-invasive (fluid in mastoid air cells) · No history of severe penicillin allergy (anaphylaxis)
Initial management with Ceftriaxone (intravenous), with the planned transition to oral antibiotics upon improvement, failed to produce clinical improvement within 48–72 hours. This lack of expected response at the 48–72 hour mark is the threshold that triggers escalation to the present protocol.