Treatment of Acute Lymphoblastic Leukemia in Patients Aged Above 55 Years

Many groups set an upper age limit for unmodified pediatric-based protocols at the age of 55 years. Patients above 55 fall outside the standard intensive regimen and require a treatment strategy specifically tailored to this population.

For patients in this age group, a transplantation-based strategy is among the approaches considered, with conditioning intensity calibrated to patient tolerance — preferably within clinical trials.

The complete regimen, eligibility criteria, and sequencing are detailed in the full protocol.