What Is the Treatment of Acute Lymphoblastic Leukemia with Allogeneic Stem Cell Transplantation?
Clinical Scenario
Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy. For eligible patients, the treatment protocol specifies a transplant-based approach with a defined myeloablative conditioning strategy — including clearly outlined criteria for when alternative conditioning is appropriate.
Treatment Approach
The protocol involves allogeneic stem cell transplantation with a specific myeloablative conditioning regimen. For patients with limited access to the primary conditioning modality, or those who cannot tolerate it, alternative conditioning regimens are defined within the protocol.
Full conditioning details, eligibility criteria, and the complete treatment algorithm are available in the structured protocol below.
References
DOI: 10.1182/blood.2023023568
- SCT provides a survival advantage for patients with poor MRD response.
- A randomized trial in pediatric ALL showed a clear benefit of myeloablative total body irradiation (TBI) (12 Gy)–based conditioning over chemotherapy-based regimens mainly because of reduced RR.
- In case of limited access to TBI or for patients who cannot tolerate this procedure, conditioning based on IV busulfan or HD thiotepa may be an alternative.
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