Pregnancy-related acute liver failure (ALF) presenting in the third trimester or immediately postpartum is a distinct and serious clinical entity. HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and acute fatty liver of pregnancy (AFLP) are its two principal obstetric causes, each requiring urgent, coordinated clinical action.
Pregnancy-specific causes of ALF include HELLP syndrome and acute fatty liver of pregnancy (AFLP). These conditions can progress rapidly and require immediate multidisciplinary assessment in the third trimester or the immediate postpartum period.
The cornerstone of management is prompt delivery of the fetus as soon as clinically feasible. Multidisciplinary supportive care runs in parallel. The full structured protocol — including timing criteria and the complete management framework — is accessible below.
DOI: 10.14309/ajg.0000000000002340
Pregnancy-specific causes of ALF include hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome and acute fatty liver of pregnancy (AFLP).
In patients with pregnancy-related ALF, supportive care and multidisciplinary management is essential, and prompt delivery of the fetus is crucial.
The cornerstone of management is prompt delivery of the fetus as soon as clinically feasible.
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