This protocol addresses acute liver failure in the setting of non-acetaminophen drug-induced liver injury — a presentation in which acetaminophen hepatotoxicity has been excluded and a causative drug is identified as the precipitant.
The patient presents with acute liver failure where acetaminophen hepatotoxicity is absent and drug-induced liver injury from another agent is the working diagnosis. Prompt identification and removal of the offending drug is central to the clinical approach.
Immediate discontinuation of the offending drug is the first critical step. An intravenous pharmacological agent is then initiated. In patients with certain immunological features, additional therapy may be considered — the full selection criteria, sequence, and regimen details are in the structured protocol.
DOI: 10.14309/ajg.0000000000002340