Neonates with severe perinatal asphyxia are at high risk of acute kidney injury in the immediate postnatal period. This protocol targets early renal protection in this specific high-risk population, where timely intervention can meaningfully alter renal outcomes.
The protocol involves theophylline as the key intervention — the complete dosing, route, and administration details are defined in the full structured regimen and are not summarised here.
Successful intervention is assessed by renal function markers during the first days of life:
DOI: 10.1159/000339789
We suggest that a single dose of theophylline may be given in neonates with severe perinatal asphyxia, who are at high risk of AKI.
The three studies all observed significantly higher GFR, higher urine output with more negative fluid balance, and lower urinary b2-microglobulin excretion, with theophylline as compared to placebo during the first 3-5 days of life.
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