Treatment of Acute Hepatitis E in Pregnancy (HEV Genotype 1 or 2)

Acute hepatitis E caused by genotype 1 or 2 in pregnant patients carries a substantially elevated risk of severe liver disease and requires prompt, specialised clinical management.

Clinical scenario

Pregnant patient with confirmed or suspected hepatitis E virus (HEV) infection, genotype 1 or 2. Pregnancy significantly alters the disease course and escalates the level of care required.

Treatment approach

The protocol specifies a specific escalation of care setting as a central management step for pregnant patients with HEV genotype 1 or 2 infection — the full structured regimen includes criteria and sequencing.

Full protocol details, criteria, and clinical decision points are in the structured regimen below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.jhep.2018.03.005

Pregnant women with HEV gt 1 or 2 should be cared for in a high-dependency setting, and transferred to a liver transplant unit if liver failure occurs.

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