Management of Acute Hepatitis B in Adults Without Impaired Synthetic Liver Function
This protocol addresses adults presenting with acute hepatitis B in whom synthetic liver function is preserved. Intact hepatic synthetic function is the defining clinical feature that shapes the management approach in this group.
Adults with acute HBV infection exhibit a high rate of spontaneous HBsAg clearance. When synthetic liver function is not impaired, this capacity for natural clearance is central to clinical decision-making and determines whether intervention is warranted.
The structured protocol outlines the evidence-based approach for this specific population — distinct from cases where synthetic function is compromised — and provides the criteria that guide ongoing assessment.
References
Given the high spontaneous clearance rate of HBsAg during acute HBV infection in adults, antiviral treatment is not required in this clinical setting as long as synthetic liver function is not impaired (strong consensus).
DOI: 10.1016/j.jhep.2025.03.018
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