Treatment of Acute Fatty Liver of Pregnancy with Severe Hepatic Impairment

Acute fatty liver of pregnancy (AFLP) is a serious obstetric emergency. When the condition is complicated by severe hepatic impairment, rapid escalation and specialist coordination are essential from the outset.

This protocol addresses women with AFLP in whom severe hepatic impairment is present. Early identification of this severity threshold is what drives the specific management pathway described in the full protocol.

In women with AFLP and severe hepatic impairment, early referral to a transplant centre is a key component of management — the full protocol specifies the criteria, decision pathway, and complete sequence of interventions involved …