Treatment of Acute Fatty Liver of Pregnancy: Multidisciplinary Stabilisation Before Delivery
Acute fatty liver of pregnancy (AFLP) is a serious obstetric emergency. Prompt diagnosis, close monitoring of both mother and fetus, and urgent coordinated care are essential to minimise harm and achieve a safe delivery.
Clinical Goals
The primary targets before delivery are correction of coagulopathy and correction of metabolic derangement, including hypoglycaemia, in order to create the safest possible conditions for the mother and fetus.
Treatment Approach
Management is led by a multidisciplinary team and begins with prompt supportive care directed at the physiological derangements above, followed by timely delivery of the fetus once stabilisation is achieved.
References
DOI: 10.1002/ijgo.70161
- It is crucial to establish a prompt diagnosis, ensure close monitoring of both the pregnant patient and fetus, provide supportive care, and expedite delivery when necessary.
- Women with acute fatty liver in pregnancy (AFLP) should be managed by the multidisciplinary team and should have coagulopathy and metabolic derangement (including hypoglycemia) corrected before prompt delivery.
- Once diagnosis is confirmed, aim to correct coagulopathy and metabolic derangement and organize delivery in a safe setting.
- The optimal mode of delivery has not been established and will vary according to the clinical scenario and expected length of time to delivery.