Treatment of Acquired von Willebrand Syndrome in Patients Undergoing Minor Surgery

Patients with acquired von Willebrand syndrome who require minor surgical procedures present a specific perioperative haemostatic challenge. Ensuring adequate haemostasis before, during, and after the procedure requires a structured, evidence-guided approach tailored to this population.

Clinical Scenario

This protocol applies to patients with acquired von Willebrand syndrome who are scheduled for minor surgery, where maintaining haemostatic control is the central perioperative concern.

Treatment Approach

Desmopressin (DDAVP) is a haemostatic consideration in this setting, with laboratory monitoring to guide repeat dosing; adjunctive antifibrinolytic therapy may also be indicated at certain surgical sites.

Full dosing, monitoring parameters, and the complete management algorithm are available in the structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.5603/ahp.107038

For patients undergoing minor surgery, desmopressin (DDAVP, 0.3 μg/kg i.v./s.c.) can be considered, with careful monitoring of vWF:Ag, FVIII:C, vWF:RCo/vWF:CB levels to guide repeat dosing due to its short effect duration.
Antifibrinolytic agents (e.g., tranexamic acid 20–25 mg/kg q8–12h) are recommended as adjunctive therapy, particularly in surgical sites with high fibrinolytic activity, such as oral or gastrointestinal mucosa.

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