Treatment of Acquired Perforating Dermatosis in Elastosis Perforans Serpiginosa with Serpentine Keratinized Papules

Clinical Scenario

This protocol addresses acquired perforating dermatosis occurring in the specific form of elastosis perforans serpiginosa (EPS) — a condition characterised by transepidermal elimination of degenerated elastic fibers.

The presentation is a distinctive rash in which keratinized papules are arranged arcuately or annularly, forming serpiginous plaques. This scenario pertains to cases not occurring in the context of D-penicillamine treatment.

Condition Detail

Elastosis perforans serpiginosum presents with the elimination of elastic fibers. The rash has a serpentine appearance with keratinized papules arranged arcuately or annularly to form plaques.

Treatment Approach — Partial Overview

Management involves topical and procedural interventions. The approach may include topical agents targeting skin repair alongside physical/light-based therapies — however, this condition is considered notably intractable.

The complete structured regimen, full option sequence, and clinical decision points are available in the full protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1111/1346-8138.15647

Elastosis perforans serpiginosum presents with the elimination of elastic fibers. The rash has a serpentine appearance with keratinized papules arranged arcuately or annularly to form plaques.

Treatments include active vitamin D3 external use, cryotherapy and laser irradiation, but they are intractable.

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