This protocol covers the management of AIDS in a person who also has latent tuberculosis infection — a co-occurring condition that directly shapes antiretroviral therapy selection and the required dosing strategy.
When AIDS occurs alongside latent tuberculosis infection, tuberculosis preventive therapy must be delivered concurrently with antiretroviral therapy. The specific preventive regimen chosen for tuberculosis determines how antiretroviral dosing must be adjusted to maintain therapeutic adequacy throughout treatment.
Management centres on a tenofovir-based antiretroviral backbone combined with an integrase strand transfer inhibitor. The dose of the integrase inhibitor requires adjustment — upward or at the standard level — depending on which tuberculosis preventive therapy regimen is selected. The full coordinated protocol, including the specific regimen pairings and their evidence ratings, is available via the link below.