Treatment of AA Amyloidosis with Severe Orthostatic Hypotension

In a subset of patients with AA amyloidosis, significant autonomic involvement leads to severe orthostatic hypotension. Although dysautonomic features are uncommon in AA amyloidosis overall, when present they can result in marked postural blood pressure drops and recurrent syncopal episodes that require targeted treatment.

AA amyloidosis with severe orthostatic hypotension — patients in whom blood pressure regulation is substantially impaired on standing, with recurrent syncope posing a significant clinical and safety concern.

Specific pharmacological measures targeting blood pressure support in the upright position have demonstrated utility in this complication. The complete agent selection and management pathway is set out in the full protocol.

The full structured regimen — including which agents apply and when — is available via the link below.

• Resolution of severe orthostatic hypotension
• Prevention of recurrent syncope